What is elucidating
Estriol was able to inhibit GPR30-mediated responses such as rapid activation of extracellular signal–regulated kinase, upregulation of target genes such as c-fos and connective tissue growth factor, and proliferative effects observed in ER-negative breast cancer cells. Oliveira AG, Coelho PH, Guedes FD, Mahecha GA, Hess RA, Oliveira CA. The androgen metabolite 5α-androstane-3β,17β-diol (3βAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance.
Dehydroepiandrosterone (DHEA) binds to ERα and ERβ, with Ki values of 1.1 and 0.5 µM, respectively. 5α-Androstane-3β,17β-diol (3β-diol), an estrogenic metabolite of 5α-dihydrotestosterone, is a potent modulator of estrogen receptor ERβ expression in the ventral prostrate of adult rats.
A positive correlation between critical shear band nucleus size and strain rate is proposed as an underlying cause of these rate dependencies.
In contrast to the selective ERα binding by other estrogens, the unique ability of estriol to bind to ERβ imparts to estriol a potential for breast cancer prevention. extracts could be a therapeutic approach to menopausal symptoms. Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor α and β subtypes: insights into the structural determinants favoring a differential subtype binding. This may provide endometrial protection via synergism between these herbal extracts, with benefits in different tissues (vascular endothelium, bone, skin, and lungs) mediated by Equol (4′,7-isoflavandiol) is an isoflavandiol metabolized from daidzein, a type of isoflavone, by bacterial flora in the intestines. crystalise, crystalize, crystallise, shed light on, sort out, crystallize, elucidate, illuminate, enlighten, straighten out, clear up, clear - make free from confusion or ambiguity; make clear; "Could you clarify these remarks?
"; "Clear up the question of who is at fault"elaborate, expatiate, expound, lucubrate, dilate, flesh out, exposit, enlarge, expand - add details, as to an account or idea; clarify the meaning of and discourse in a learned way, usually in writing; "She elaborated on the main ideas in her dissertation"At the back of the estrade, and attached to a moveable partition dividing this schoolroom from another beyond, was a large tableau of wood painted black and varnished; a thick crayon of white chalk lay on my desk for the convenience of any grammatical or verbal obscurity which might occur in my lessons by writing it upon the tableau; a wet sponge appeared beside the chalk, to enable me to efface the marks when they had served the purpose intended.In the prostate, ERβ is highly expressed in the epithelial compartment, where it is the prevailing isoform.
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